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CpMashaBabkoWmv __HOT__

CpMashaBabkoWmv ===

CpMashaBabkoWmv __HOT__

CpMashaBabkoWmv.Prevalence of 22 polymorphisms and haplotype associations with systemic lupus erythematosus in the HapMap (HCB+CEU) population. Several association studies have been conducted in the last years in order to establish the relation of single nucleotide polymorphisms and haplotypes with systemic lupus erythematosus (SLE) in different populations. Our aim was to evaluate the extent of these associations in our population. Of all the known polymorphisms in SLE genes, only 22 were studied in the population of Hispanic Caucasians (HapMap). Population frequencies and linkage disequilibrium (LD) were obtained from the HapMap data set. In this study, we included 22 polymorphisms in 20 SLE genes as follows: VDR (BsmI, FokI, TaqI, ApaI, CdxA), CYP24A1 (A>G), IL2 (T>A), CD28 (C>G), ADRB2 (Gly16Glu), CTLA4 (A>G), CD40 (G>A), CD80 (T>C), CTLA-4 (rs231775), TRAF1 (CT>CA), TRAF2 (G>A), TRAF3 (A>G), TRAF6 (G>A), NFKB1 (T>A), FLT3 (T>C), FYB (C>T), HDAC2 (G>A), EGR1 (T>C), PTGER1 (G>A), PTGER4 (G>A), and PTGER2 (G>A). As expected, we confirmed a high degree of LD between most polymorphisms. However, we observed a LD between CTLA4 (rs231775) and TRAF2 (G>A) in our population which was not described in Caucasian or Asian populations in HapMap. The most frequent haplotype in the HapMap population, b.A.A.A.A.A.T.T.G was not associated with SLE, whereas the haplotype T.A.G.G.T.A.G which was found in our population, b.A.A.A.A.G.T.G, was more frequent in Mexican SLE patients. Some of the associations previously reported in other populations were also found in the HapMap population. In addition, we found some differences in the frequencies of haplotypes and single nucleotide polymorphisms in Mexican SLE patients when compared to Caucasians. 3d9ccd7d82

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